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How the Brain Prepares to Think

nitial configuration of the molecular dynamics simulations designed to investigate the nature of the primed state of synaptic vesicles.

Said University of Texas professor Jose Rizo-Rey, "This country was very successful because of basic research. Translation is important, but if you don't have the basic science, you have nothing to translate."

Credit: Jose Rizo-Rey, University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center's Jose Rizo-Rey and colleagues used the Texas Advanced Computing Center's Frontera supercomputer to probe the physics of thought activation in the brain.

The researchers have generated all-atom molecular dynamics simulations to explore the nature of the primed state of synaptic vesicles, indicating specialized proteins are "spring-loaded" and awaiting calcium ions to induce fusion.

The models only simulate the first few microseconds of the fusion process, but Rizo-Rey posits that fusion should occur in that time.

Rizo-Rey said, "If I see how it's starting, the lipids starting to mix, then I'll ask for 5 million hours [the maximum time available] on Frontera" to record the spring-loaded proteins' trigger and the fusion/transmission process.

From Texas Advanced Computing Center
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