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Model Translates Heart Research Findings From Animals to Humans


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Said Stefano Morotti, assistant professor in pharmacology at the University of California Davis School of Medicine, Implications of inter-species differences are significant in the pharmaceutical field, where there are growing concerns about the safety and efficacy of drugs tested on animals.

Credit: health.ucdavis.edu

Scientists at the University of California, Davis and the U.S. Department of Energy's Lawrence Berkeley National Laboratory have developed a predictive computer model that expresses animal cardiac research as human-specific insights.

The researchers designed a suite of translators for mapping the electrophysiological response of mouse, rabbit, and human cardiac cells.

The model can enable animal-to-human translation of electrophysiological measurements such as the effects of drugs, heart rate irregularities, or changes caused by heart disease.

The researchers also demonstrated that the tools can help to devise experiments that maximize translatability to human physiology.

From UC Davis Health
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Abstracts Copyright © 2021 SmithBucklin, Washington, DC, USA


 

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