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Imaging the Secret Lives of Immune Cells in the Eye

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Microscopic immune cells escaping a nearby blood vessel in response to inflammation.

University of Rochester researchers combined infrared videography and artificial intelligence to track the interactions of microscopic immune cells in a living eye without dyes or damage.

Credit: Schallek laboratory, University of Rochester

University of Rochester (UR) researchers have developed a technique for imaging and tracking the interactions of microscopic immune cells in a living eye, without using dyes or causing damage.

The method builds on adaptive optics developed at UR more than two decades ago, with time-lapse infrared videography and artificial intelligence (AI) software added.

The videography captures images of immune cell activity in the retina over periods ranging from milliseconds to months, and the AI code identifies the different types of immune cells captured in the images.

Ultra-high-speed imaging of individual red blood cells can simultaneously monitor blood flow and how it changes in response to inflammation.

UR's Jesse Schallek said, "We think this will be a game changer for ophthalmology and for our understanding of retinal diseases that lead to blindness."

From University of Rochester Newscenter
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Abstracts Copyright © 2020 SmithBucklin, Washington, DC, USA


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