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Communications of the ACM

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Computer Model Predicts How Drugs Affect Heart Rhythm


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Arrythmia could be an unintended side effect of a new drugs.

A computer model developed by University of California, Davis researchers can screen new drugs from unanticipated side effects.

Credit: NewsKarnataka

Researchers at the University of California, Davis (UC Davis) have developed a computer model that can screen drugs for unintended cardiac side effects, such as arrhythmia.

The model uses a drug's chemical formula to reveal how that drug specifically interacts with hERG-encoded potassium channels essential to normal heart rhythm, as well as with cardiac cells and tissue.

The outcomes can then be validated with comparisons to clinical data from electrocardiogram (ECG) results of patients.

Said UC Davis researcher Colleen E. Clancy, "Every new drug needs to go through a screening for cardiac toxicity, and this could be an important first step to suggesting harm or safety before moving on to more expensive and extensive testing."

From University of California, Davis
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Abstracts Copyright © 2020 SmithBucklin, Washington, DC, USA


 

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