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Next Generation of Organ-on-Chip Has Arrived


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The Wyss Institute human body-on-chip system is layered on top of the Leonardo da Vinci ink drawing of the Vitruvian Man, representing ideal human body proportions.

Researchers at Harvard University's Wyss Institute for Biologically Inspired Engineering have created a modular organ-on-a-chip platform.

Credit: Wyss Institute at Harvard University

Researchers at Harvard University's Wyss Institute for Biologically Inspired Engineering have met the U.S. Defense Advanced Research Projects Agency (DARPA) challenge to create next-generation organ-on-a-chip models.

The researchers developed a modular platform that incorporates the Interrogator instrument to culture, perfuse, and connect organic human-cultured tissues in a multi-organ chip system, while sampling the medium in a fully programmable manner. In another study, the researchers utilized a computational scaling technique to incorporate results from drug experiments involving three distinct types of fluidically linked organ chips to their respective organ dimensions in the human body.

Harvard's Donald Ingber said, "We hope our demonstration that this level of biomimicry is possible using organ chip technology will garner even greater interest from the pharmaceutical industry so that animal testing can be progressively reduced over time."

From The Harvard Gazette 
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Abstracts Copyright © 2020 SmithBucklin, Washington, DC, USA


 

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