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Image-Based Computer Model Reveals Finer Details of Tumor Blood Flow Behavior

Maps of tumors grown in mice.

Johns Hopkins Medicine researchers have developed what they're calling a Google Maps approach to more accurately compute and visualize the structural and functional blood vessel changes needed for tumor growth.

Credit: Arvind Pathak

Johns Hopkins Medicine researchers have developed a computer simulation of tumor behavior that accurately encapsulates finer blood-flow patterns and how they engineer cancer growth.

The model couples three-dimensional (3D) magnetic resonance microscopy and micro-computed tomographic imaging of tumor samples from mice with refined mathematical formulas to enable precise mapping of the blood vessel structure.

The researchers developed a set of mathematical formulas based on data from previous studies, and their own, and converted the resulting data into an easy-to-visualize format.

The result was a 3D rendering of the blood vessel network in each tumor, featuring a color-coded map of blood traffic through vessels that fed growth.

From Johns Hopkins Medicine Newsroom
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Abstracts Copyright © 2019 SmithBucklin, Washington, DC, USA


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