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­t Arlington Researchers Successfully Test Model For Implant Device Reactions


Almost all medical implants cause some degree of foreign body reaction, which can cause severe inflammation and the formation of fibrotic capsules in surrounding tissue.

Researchers at the University of Texas at Arlington have unveiled a new computer simulation that could improve the treatment of extreme reactions to medical implants.

Credit: University of Texas at Arlington

University of Texas at Arlington (UT Arlington) researchers have developed a computer simulation that could improve the treatment of dangerous reactions to medical implants such as stents, catheters, and artificial joints.

The results from the research on foreign-body reaction to implants were consistent with biological models in lab tests. "This model will allow us to improve the biocompatibility of medical devices and identify the timing and dosages of treatments when reactions occur," says UT Arlington professor Liping Tang.

The researchers divided microphages into three types based on their functions. They then constructed a series of mathematical equations based on the kinetic characteristics of the microphages and connective tissue. The researchers overcome the scarcity of data by learning from what happens in wound healing because it is a similar biological process. "Research universities such as UT Arlington are at their best when they bring together great thinkers and encourage them to reach outside their academic silos to solve scientific questions," says UT Arlington's Carolyn Cason.

From University of Texas at Arlington
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