In the course of our work on the physical chemistry of histamine and related compounds, we have done extensive work involving potentiometric titration of systems of chelates of these ligands with various metallic ions, negative ions, and small molecules. The resulting data is used to calculate the stability constants in solution (1, 2, 3, 4). The mathematical calculations for a single titration require two to four hours when done on a desk calculator, even when the operator is experienced. This is a serious disadvantage of the technique. The more accurate methods of successive approximations and of simultaneous equations  are so time consuming that their routine use is impractical without the aid of a high speed computer.
The full text of this article is premium content
No entries found
Log in to Read the Full Article
Please select one of the options below for access to premium content and features.
Create a Web Account
If you are already an ACM member, Communications subscriber, or Digital Library subscriber, please set up a web account to access premium content on this site.
Join the ACM
Become a member to take full advantage of ACM's outstanding computing information resources, networking opportunities, and other benefits.
Subscribe to Communications of the ACM Magazine
Get full access to 50+ years of CACM content and receive the print version of the magazine monthly.
Purchase the Article
Non-members can purchase this article or a copy of the magazine in which it appears.